Changes Configure: Changed compiler flags to support large files for OS calls. Licence: Changed licence links. Perl Scripts: Replaced newer perl object oriented file handle syntax with old form as it was causing perl v5.8.0 to crash. Files changed in patch: website/html/meme-download.html website/html/downloads.html website/cgi-bin/meme_request.pl Installing the patch 1) Ensure all previous patches have been installed. 2) change into the meme_4.4.0 directory. 3) run patch -p0 -i PATH_TO_PATCH/meme_4.4.0.patch_3 4) run make clean 5) run make CFLAGS="$(getconf LFS_CFLAGS)" (with the quotes) 6) and finally if you want to propagate the new build to the install directory, run make install